Perioperative Analgesic Effect Of Erector Spinae Block In Pigs Undergoing Thoracic Surgery: Preliminary Results
Nocera I1, Di Franco C2, Paganelli A1, Gabisonia K1, Modu M1, Carlucci L1, Briganti A3
1Institute of Health Science, Sant'Anna School Of Advanced Study, Pisa, Italy, 2Institute of Clinical Physiology, CNR San Cataldo Research Area, Pisa, Italy, 3Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, Pisa, Italy.
Objectives:
The erector spinae block (ESB) is effective in controlling pain in thoracic surgery and chest trauma in both human and veterinary patients. This study aimed to evaluate the perioperative analgesic effect of the ESB in pigs undergoing lateral thoracotomy.
Methods:
For this blind randomised study, 18 pigs undergoing iatrogenic myocardial infarction were included. They were randomly divided into 2 groups: group Ropi received unilateral ropivacaine 0.5% 0.3 mL/kg at the 6th thoracic vertebra with a caudocranial in-plane ultrasound-guided injection; and group NaCl received ESB as saline solution in equal volume. Systemic blood pressure, heart rate, end-tidal CO2, and end-tidal sevoflurane were recorded during anaesthesia. Pain was recorded 24 and 48 hours post-surgery, according to the UNESP-Botucatu pig pain scale. One-way ANOVA with a Tukey post hoc was used to compare the measurements for each time point within each group, while a student t-test or a Mann-Whitney test was used to compare the 2 groups. Significance was set at p<0.05. The study was approved by the Italian Ministry of Health (n°0622).
Results:
During the procedure, heart rate and end-tidal sevoflurane values were significantly higher in the NaCl group compared to the Ropi group (
P<0.05). The Ropi group showed a significantly lower mean pain score of 1 (0-3), compared to the NaCl group of 3.5 (2-9) (
P=0.005) 48 hours post-surgery, and within the Ropi group of 2 (1-8) at 24hrs post-surgery and 48hrs (
P=0.004).
Conclusions:
Including ESB with ropivacaine 0.5% improved the quality of perioperative analgesia in pigs undergoing thoracic surgery.