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Objectives:
Canine mast cell tumors (MCTs) are primary skin neoplasms, originating in cutaneous (cMCT) or subcutaneous tissues (scMCT). While existing literature on MCTs mainly concentrates on cMCTs, only a minor portion focuses on scMCTs as a distinct identity, suggesting a less aggressive behavior in this group. Histologic grading systems (Patnaik and Kiupel) were developed for cMCTs, which has led to challenges in evaluating scMCTs. The objective of this study was to describe potential differences in signalment and histopathological features between cMCTs and scMCTs.
Methods:
Data regarding cMCTs and scMCTs between September 2020 and July 2023 were gathered from 3 independent pathology databases and included signalment, tumor location, histopathological features, completeness of removal, and lymph node involvement.
Results:
There were 1291 cMCT versus 646 scMCT reports. Mitotic count was not different between cMCT (mean 2.7 +/- 12.4) and scMCT (1.8 +/- 7.5) (p < 0.099). Of the 317/646 scMCTs that were graded according to the Kiupel system, 17.4% (55/317) were assigned a high-grade, as opposed to 11.9% (144/1291) of the cMCTs (p = 0.01432). Information on lymph node metastasis was available in 95/1937 MCT and metastasis was present in 19/39 (48.7%) cMCTs and in 36/56 (64.3%) scMCTs (p = 0.06232).
Conclusions:
Subcutaneous MCTs were more frequently classified as Kiupel high-grade than cMCTs. This suggests that scMCTs might exhibit a more aggressive histological behavior, the opposite of what has been previously suggested. Mitotic count did not differ between both groups. Lymph node metastasis in scMCTs might be more common than currently documented.
34th Annual Scientific Meeting proceedings
Stream:
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Session: Resident Forum - Soft Tissue
Date/Time: 04-07-2024 (18:15 - 18:30) | Location: Auditorium 4
Date/Time: 04-07-2024 (18:15 - 18:30) | Location: Auditorium 4
Signalment and histopathological features of subcutaneous versus cutaneous mast cell tumors
Minnoye SM1, De Vos SDV2, Beck SB3, Scase TS4, Pittaway RP5, Duchateau LD6, David SD2, Hubers MH*7, Fortrie RF*1, De Rooster HDR*2
1Anicura Dierenkliniek Randstad, Antwerp, Belgium, 2Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium, 3Independent Anatomic Pathology Ltd, Taunton, United Kingdom, 4Bridge Pathology Ltd, Bristol, United Kingdom, 5Dick White Referrals, Six Mile Bottom, United Kingdom, 6Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium, 7Department of Orthopaedic Surgery, Medisch Centrum Voor Dieren, Amsterdam, Netherlands.
Objectives:
Canine mast cell tumors (MCTs) are primary skin neoplasms, originating in cutaneous (cMCT) or subcutaneous tissues (scMCT). While existing literature on MCTs mainly concentrates on cMCTs, only a minor portion focuses on scMCTs as a distinct identity, suggesting a less aggressive behavior in this group. Histologic grading systems (Patnaik and Kiupel) were developed for cMCTs, which has led to challenges in evaluating scMCTs. The objective of this study was to describe potential differences in signalment and histopathological features between cMCTs and scMCTs.
Methods:
Data regarding cMCTs and scMCTs between September 2020 and July 2023 were gathered from 3 independent pathology databases and included signalment, tumor location, histopathological features, completeness of removal, and lymph node involvement.
Results:
There were 1291 cMCT versus 646 scMCT reports. Mitotic count was not different between cMCT (mean 2.7 +/- 12.4) and scMCT (1.8 +/- 7.5) (p < 0.099). Of the 317/646 scMCTs that were graded according to the Kiupel system, 17.4% (55/317) were assigned a high-grade, as opposed to 11.9% (144/1291) of the cMCTs (p = 0.01432). Information on lymph node metastasis was available in 95/1937 MCT and metastasis was present in 19/39 (48.7%) cMCTs and in 36/56 (64.3%) scMCTs (p = 0.06232).
Conclusions:
Subcutaneous MCTs were more frequently classified as Kiupel high-grade than cMCTs. This suggests that scMCTs might exhibit a more aggressive histological behavior, the opposite of what has been previously suggested. Mitotic count did not differ between both groups. Lymph node metastasis in scMCTs might be more common than currently documented.
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